A Study of Epacadostat in Combination With Pembrolizumab and Chemotherapy in Participants With Advanced or Metastatic Solid Tumors (ECHO-207/KEYNOTE-723)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

May 2, 2017

Primary Completion Date

January 25, 2019

Study Completion Date

July 13, 2020

Conditions
Solid Tumor
Interventions
DRUG

Epacadostat

Epacadostat oral twice-daily continuous daily dosing at the protocol-defined dose.

DRUG

Pembrolizumab

Pembrolizumab

DRUG

Oxaliplatin

Oxaliplatin

DRUG

Leucovorin

Leucovorin

DRUG

5-Fluorouracil

5-Fluorouracil

DRUG

Gemcitabine

Gemcitabine

DRUG

nab-Paclitaxel

nab-Paclitaxel

DRUG

Carboplatin

Carboplatin

DRUG

Paclitaxel

Paclitaxel

DRUG

Pemetrexed

Pemetrexed

DRUG

Cyclophosphamide

Cyclophosphamide

DRUG

Carboplatin

Carboplatin

DRUG

Cisplatin

Cisplatin

DRUG

5-Fluorouracil

5-FU

DRUG

Investigator's choice of platinum agent

Investigator's choice of platinum agent: carboplatin or cisplatin

Trial Locations (16)

10065

Memorial Sloan Kettering Cancer Center, New York

15237

University of Pittsburgh Cancer Institute, Pittsburgh

19104

University of Pennsylvania Health System, Philadelphia

28078

Carolina Bio-Oncology Institute, PLLC, Huntersville

32224

Mayo Clinic, Jacksonville

37203

Tennessee Oncology - Nashville; The Sarah Cannon Research Institute, Nashville

37232

Vanderbilt University; Henry Joyce Cancer Clinic, Nashville

55905

Mayo Clinic, Rochester

60637

University of Chicago, Chicago

63110

Washington University School of Medicine, St Louis

77030

MD Anderson Cancer Center, Houston

84112

Huntsman Cancer Institute at University of Utah, Salt Lake City

85054

Mayo Clinic Arizona, Phoenix

90025

The Angeles Clinic and Research Institute, Los Angeles

92093

University of California San Diego Medical Center, Moores Cancer Center, La Jolla

97239

Oregon Health and Science University, Portland

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Incyte Corporation

INDUSTRY