Study of LN-145/LN-145-S1 Autologous Tumor Infiltrating Lymphocytes in the Treatment of Squamous Cell Carcinoma of the Head & Neck

PHASE2CompletedINTERVENTIONAL
Enrollment

64

Participants

Timeline

Start Date

January 9, 2017

Primary Completion Date

August 8, 2022

Study Completion Date

August 8, 2022

Conditions
Squamous Cell Carcinoma of the Head and Neck
Interventions
BIOLOGICAL

LN-145

A tumor sample is resected from each patient and cultured ex vivo to expand the population of tumor infiltrating lymphocytes. After NMA lymphodepletion, patients are infused with their autologous TIL (LN-145) followed by IL-2 administration.

BIOLOGICAL

LN-145-S1

A tumor sample is resected from each patient and cultured ex vivo to expand the population of tumor infiltrating lymphocytes. After NMA lymphodepletion, patients are infused with autologous TIL (LN-145-S1) followed by IL-2 administration.

Trial Locations (22)

15213

UPMC Hillman Cancer Center, Pittsburgh

19718

Christiana Care Health System, Newark

21201

University of Maryland, Baltimore

27599

University of North Carolina, Chapel Hill

33612

Moffitt Cancer Center, Tampa

35294

University of Alabama, Birmingham

40202

University of Louisville, Louisville

46202

Indiana University, Indianapolis

48201

Barbara Ann Karmanos Cancer Institute, Detroit

53226

Medical College of Wisconsin, Milwaukee

57105

Avera Cancer Institute, Sioux Falls

60611

Northwestern University, Chicago

60637

University of Chicago, Chicago

66205

University of Kansas, Westwood

70112

Louisiana State University - Health Sciences Center, New Orleans

80045

University of Colorado, Aurora

90024

University of California, Los Angeles, Los Angeles

90033

University of Southern California, Los Angeles

92093

University of California San Diego, La Jolla

97213

Providence Cancer Center Oncology and Hematology Care Clinic, Portland

98195

University of Washington, Seattle

07960

Morristown Medical Center, Morristown

Sponsors
All Listed Sponsors
lead

Iovance Biotherapeutics, Inc.

INDUSTRY

NCT03083873 - Study of LN-145/LN-145-S1 Autologous Tumor Infiltrating Lymphocytes in the Treatment of Squamous Cell Carcinoma of the Head & Neck | Biotech Hunter | Biotech Hunter