NCT03079921View on ClinicalTrials.gov

Adrenergic System in Islet Transplantation

EARLY_PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

11

Participants

Timeline

Start Date

January 20, 2017

Primary Completion Date

April 30, 2019

Study Completion Date

December 31, 2025

Conditions
Type1diabetesHypoglycemiaHypoglycemia UnawarenessIslet Cell Transplantation
Interventions
DRUG

Phentolamine

Physiologic receptor blockade (α1-receptor).

DRUG

Propranolol

Physiologic receptor blockade (β2-receptor).

DRUG

Placebo

100mL bag of Normal Saline Solution (NSS).

Trial Locations (1)

19104

University of Pennsylvania - Institute for Diabetes, Obesity and Metabolism, Philadelphia

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

collaborator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

lead

University of Pennsylvania

OTHER