Characterization of the Neo-squamous Epithelial Barrier

CompletedOBSERVATIONAL
Enrollment

53

Participants

Timeline

Start Date

September 26, 2016

Primary Completion Date

November 1, 2019

Study Completion Date

June 29, 2022

Conditions
Barrett's Esophagus With Dysplasia
Interventions
DEVICE

Mucosal Impedance

Aim 1: Mucosal impedance will be measured by an endoscopic probe 1 cm above the gastroesophageal junction, 5 cm above the gastroesophageal junction and in the proximal esophagus in an area not exposed to the index therapeutic radiofrequency ablation. Aim 2: Mucosal impedance will be measured 1 cm above gastroesophageal junction, 1 cm below previous squamous columnar junction, 1 cm above previous squamocolumnar junction.

OTHER

Research Biopsies

Aim 1: Research biopsies will be obtained at 1 cm above the gastroesophageal junction, 5 cm above the gastroesophageal junction, and in the proximal esophagus in an area not exposed to the index therapeutic radiofrequency ablation. Aim 2: Aim 2: Research biopsies will be taken 1 cm above gastroesophageal junction, 1 cm below previous squamous columnar junction, 1 cm above previous squamocolumnar junction.

DEVICE

Volumetric Laser Endomicroscopy

Aim 2: Volumetric laser endomicroscopy will be done and marked at 1 cm above gastroesophageal junction, 1 cm below previous squamous columnar junction, 1 cm above previous squamocolumnar junction.

Trial Locations (2)

10032

Columbia University Medical Center, New York

55905

Mayo Clinic, Rochester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Mayo Clinic

OTHER

NCT03077594 - Characterization of the Neo-squamous Epithelial Barrier | Biotech Hunter | Biotech Hunter