PREPARE, Prematurity Reduction by Pre-eclampsia Care

NACompletedINTERVENTIONAL
Enrollment

1,250

Participants

Timeline

Start Date

December 1, 2016

Primary Completion Date

December 30, 2019

Study Completion Date

June 20, 2020

Conditions
Pre-EclampsiaPremature Birth
Interventions
DIAGNOSTIC_TEST

FullPIERS and sFlit/PLGF (Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio)

Once the centre is randomised to receive the intervention, all eligible women will have serum sFlt1/PlGF measurement performed and fullPIERS assessment and both results will be revealed to the care providers. This will include all women with pre-eclampsia or suspected pre-eclampsia cared for at the main hospital centres (and not be limited to women referred to the hospital from the community health centres). sFlt-1/PlGF will be tested by immunoassays (Roche Platform®). The result read out is provided by specific machines provided by Roche in less than one hour, which permits rapid clinical decision-making. Risk stratification using fullPIERS will be performed on tablet computers using a pre-defined risk scoring system integrated within the MedSciNet database.

Trial Locations (8)

20021140

Instituto Fernandes Figueira, Rio de Janeiro

90.035-903

Hospital de Clinicas de Porto Alegre, Porto Alegre

18618-681

Maternidade Unesp Botucatu, Botucatu

13084-881

Caism - Unicamp, Campinas

11045-904

Hospital Guilherme Alvaro, Santos

20211-340

Maternidade Maria Amelia Buarque de Holanda, Rio de Janeiro

22775-003

Maternidade Leila Diniz, Rio de Janeiro

03015-000

Hospital Maternidade Leonor Mendes de Barros, São Paulo

Sponsors

Collaborators (2)

All Listed Sponsors
lead

Instituto Fernandes Figueira

OTHER_GOV

collaborator

CoLab

UNKNOWN

collaborator

SMSDC/RJ

UNKNOWN

collaborator

University of Campinas, Brazil

OTHER

collaborator

UPECLIN HC FM Botucatu Unesp

OTHER

collaborator

HGA

UNKNOWN

collaborator

HOSPITAL MATERNIDADE LEONOR MENDES DE BARROS

UNKNOWN

collaborator

Hospital de Clinicas de Porto Alegre

OTHER

NCT03073317 - PREPARE, Prematurity Reduction by Pre-eclampsia Care | Biotech Hunter | Biotech Hunter