ALXN1210 Versus Eculizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Eculizumab

PHASE3CompletedINTERVENTIONAL
Enrollment

202

Participants

Timeline

Start Date

May 17, 2017

Primary Completion Date

February 21, 2022

Study Completion Date

February 21, 2022

Conditions
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Interventions
BIOLOGICAL

Ravulizumab

All treatments were given as intravenous (IV) infusions. For participants weighing ≥40 to \<60 kilograms (kg): 2400 mg was given as a single loading dose, followed by 3000 mg as maintenance dose. For participants weighing ≥60 to \<100 kg: 2700 mg was given as a loading dose, followed by 3300 mg as maintenance dose. For participants weighing ≥100 kg: 3000 mg was given as a loading dose, followed by 3600 mg as maintenance dose.

BIOLOGICAL

Eculizumab

All treatments were given as IV infusions. Participants received 900 mg of eculizumab q2w.

Trial Locations (51)

2170

Research Site, Liverpool

2217

Research Site, Kogarah

2605

Research Site, Canberra

3000

Research Site, Melbourne

3722

Research Site, Seoul

4102

Research Site, Woolloongabba

6591

Research Site, Seoul

8036

Research Site, Barcelona

10126

Research Site, Torino

10467

Research Site, The Bronx

13273

Research Site, Marseille

14584

Research Site, Bucheon-si

16247

Research Site, Suwon

20122

Research Site, Milan

21205

Research Site, Baltimore

21565

Research Site, Incheon

28040

Research Site, Madrid

28220

Research Site, Majadahonda

35015

Research Site, Daejeon

36100

Research Site, Vicenza

38043

Research Site, La Tronche

42270

Research Site, Saint-Priest-en-Jarez

42415

Research Site, Daegu

45147

Research Site, Essen

48202

Research Site, Detroit

50134

Research Site, Florence

52074

Research Site, Aachen

67091

Research Site, Strasbourg

69495

Research Site, Pierre-Bénite

75475

Research Site, Paris

80054

Research Site, Amiens

80131

Research Site, Napoli

89081

Research Site, Ulm

90089

Research Site, Los Angeles

91010

Research Site, Duarte

M4N 3M5

Research Site, Toronto

M5G 2C4

Research Site, Toronto

H1T 2M4

Research Site, Montreal

06200

Research Site, Nice

960-1295

Research Site, Fukushima

920-8641

Research Site, Kanazawa

141-0022

Research Site, Shinagawa-ku

565-0871

Research Site, Suita-shi

392-8510

Research Site, Suwa-shi

6202 AZ

Research Site, Maastricht

6525 GA

Research Site, Nijmegen

03080

Research Site, Seoul

06351

Research Site, Seoul

ML6 0JS

Research Site, Airdrie

LS9 7TF

Research Site, Leeds

SE5 9NU

Research Site, London

Sponsors
All Listed Sponsors
lead

Alexion Pharmaceuticals, Inc.

INDUSTRY