A(B)VD Followed by Nivolumab as Frontline Therapy for Higher Risk Patients With Classical Hodgkin Lymphoma (HL)

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

82

Participants

Timeline

Start Date

January 25, 2017

Primary Completion Date

January 31, 2026

Study Completion Date

January 31, 2026

Conditions
Hodgkin Lymphoma
Interventions
DRUG

doxorubicin

Doxorubicin: 25 mg/m\^2 will be administered by IV infusion on Days 1 and 15 of each 28-day cycle

DRUG

Bleomycin

Bleomycin: 10 units/m\^2 will be administered by IV infusion on Days 1 and 15 of each 28-day cycle

DRUG

vinblastine

Vinblastine: 6 mg/m\^2 will be administered by IV infusion on Days 1 and 15 of each 28-day cycle

DRUG

dacarbazine

Dacarbazine (DTIC): 375 mg/m\^2 will be administered by IV infusion on Days 1 and 15 of each 28-day cycle.

DRUG

Nivolumab

nivolumab 240mg q14 days

Trial Locations (10)

10065

Memorial Sloan Kettering Cancer Center, New York

10604

Memorial Sloan Kettering Westchester, Harrison

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

48201

Karmanos Cancer Institute, Detroit

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07601

Hackensack Meridian Health, Hackensack

07748

Memorial Sloan Kettering Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

V5Z4E6

BC Cancer (Data Collection Only), Vancouver

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Barbara Ann Karmanos Cancer Institute

OTHER

collaborator

British Columbia Cancer Agency

OTHER

lead

Memorial Sloan Kettering Cancer Center

OTHER