African-Canadian Study of HIV-Infected Adults and a Vaccine for Ebola - ACHIV-Ebola

The rVSVΔG-ZEBOV-GP vaccine is a live attenuated recombinant virus consisting of a single recombinant VSV isolate (11481 nt, strain Indiana) with the gene for the Zaire ebolavirus GP (ZEBOV GP), Kikwit strain replacing the gene for the VSV GP, which has been deleted. This results in a VSV backbone with the ZEBOV GP constituting the envelope of the virus.

Normal saline (0.9%) has been chosen as an inert substance to serve as placebo control.