47
Participants
Start Date
February 12, 2018
Primary Completion Date
December 12, 2025
Study Completion Date
April 12, 2026
Pembrolizumab
Given intravenously in clinic, at 200 mg, on Day 1 of every 21-day cycle.
DPX-Survivac
Given by injection under the skin of the upper thigh in clinic. Participants will receive one priming dose of 0.25 mL of DPX-Survivac on Cycle 1 Day 1. After about 6 weeks, participants will receive an additional boosting dose of 0.25 or 0.5 mL DPX-Survivac.
Cyclophosphamide
Given orally, at 50 mg, twice a day, starting about 7 days before Cycle 1 Day 1, then continue 7 days off, 7 days on.
Princess Margaret Cancer Centre, Toronto
Merck Sharp & Dohme LLC
INDUSTRY
ImmunoVaccine Technologies, Inc. (IMV Inc.)
INDUSTRY
University Health Network, Toronto
OTHER