Phase 2 Study of Pembrolizumab, DPX-Survivac Vaccine and Cyclophosphamide in Advanced Ovarian, Primary Peritoneal or Fallopian Tube Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

February 12, 2018

Primary Completion Date

December 12, 2025

Study Completion Date

April 12, 2026

Conditions
Advanced CancerOvarian CancerPrimary Peritoneal CarcinomaFallopian Tube Cancer
Interventions
DRUG

Pembrolizumab

Given intravenously in clinic, at 200 mg, on Day 1 of every 21-day cycle.

BIOLOGICAL

DPX-Survivac

Given by injection under the skin of the upper thigh in clinic. Participants will receive one priming dose of 0.25 mL of DPX-Survivac on Cycle 1 Day 1. After about 6 weeks, participants will receive an additional boosting dose of 0.25 or 0.5 mL DPX-Survivac.

DRUG

Cyclophosphamide

Given orally, at 50 mg, twice a day, starting about 7 days before Cycle 1 Day 1, then continue 7 days off, 7 days on.

Trial Locations (1)

M5G 2M9

Princess Margaret Cancer Centre, Toronto

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

ImmunoVaccine Technologies, Inc. (IMV Inc.)

INDUSTRY

lead

University Health Network, Toronto

OTHER