Atezolizumab in Combination With Entinostat and Bevacizumab in Patients With Advanced Renal Cell Carcinoma

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

31

Participants

Timeline

Start Date

June 29, 2017

Primary Completion Date

June 24, 2024

Study Completion Date

June 24, 2024

Conditions
Metastatic CancerRenal Cancer
Interventions
DRUG

Atezolizumab

Atezolizumab will be given intravenously every 3 weeks at 1200 mg.

DRUG

Bevacizumab

Bevacizumab will be given intravenously every 3 weeks at 15 mg/kg.

DRUG

Entinostat

Entinostat will be given orally every 7 days at 1, 3, or 5 mg depending upon phase. In Phase I, dose levels will be tested in up to 3 cohorts starting at 1 mg. In Phase II, the dose will be the recommended phase II dose that was determined during Phase I (i.e., 1, 3, or 5 mg).

Trial Locations (4)

19104

University of Pennsylvania, Philadelphia

43210

Ohio State University, Columbus

46202

Indiana University Health Hospital, Indianapolis

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis

Sponsors
All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

collaborator

Syndax Pharmaceuticals

INDUSTRY

lead

Roberto Pili

OTHER