NCT03017820 - A Vaccine (VSV-hIFNβ-NIS) With or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in Treating Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia or Lymphoma | Biotech Hunter

Enrollment

127

Participants

Timeline

Start Date

April 4, 2017

Primary Completion Date

December 31, 2028

Study Completion Date

April 1, 2032

Conditions

B-Cell Non-Hodgkin LymphomaHistiocytic and Dendritic Cell NeoplasmMyelodysplastic SyndromePreviously Treated Myelodysplastic SyndromeRecurrent Adult Acute Myeloid LeukemiaRecurrent Anaplastic Large Cell LymphomaRecurrent Angioimmunoblastic T-Cell LymphomaRecurrent Mycosis FungoidesRecurrent Plasma Cell MyelomaRecurrent Primary Cutaneous T-Cell Non-Hodgkin LymphomaRecurrent T-Cell Non-Hodgkin LymphomaRefractory Acute Myeloid LeukemiaRefractory Anaplastic Large Cell LymphomaRefractory Angioimmunoblastic T-Cell LymphomaRefractory Mycosis FungoidesRefractory Peripheral T-Cell Lymphoma, Not Otherwise SpecifiedRefractory Plasma Cell MyelomaRefractory Primary Cutaneous T-Cell Non-Hodgkin LymphomaRefractory T-Cell Non-Hodgkin Lymphoma

Interventions

PROCEDURE

Biopsy Procedure

Undergo tumor or lymph node biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Bone Marrow Biopsy

Undergo bone marrow biopsy

PROCEDURE

Computed Tomography

Undergo SPECT/CT

DRUG

Cyclophosphamide

Given IV

PROCEDURE

Positron Emission Tomography

Undergo PET scan

BIOLOGICAL

Recombinant Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide Symporter

Given IV

PROCEDURE

Single Photon Emission Computed Tomography

Undergo SPECT/CT

BIOLOGICAL

Cemiplimab

Given IV

DRUG

Ruxolitinib

Given PO

BIOLOGICAL

ipilimumab

Given IV

BIOLOGICAL

Nivolumab

Given IV

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA scan

PROCEDURE

Echocardiography Test

Undergo echocardiography

PROCEDURE

Bone Marrow Aspiration

Undergo bone marrow aspiration

Trial Locations (2)

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

85259

RECRUITING

Mayo Clinic in Arizona, Scottsdale