NCT03016806View on ClinicalTrials.gov

Umbilical Cord Blood Transplantation From Unrelated Donors

RecruitingOBSERVATIONAL
Enrollment

30

Participants

Timeline

Start Date

June 30, 2015

Primary Completion Date

June 30, 2027

Study Completion Date

June 30, 2027

Conditions
Acute LeukemiaImmune Deficiency DisorderCongenital Hematological DisorderMetabolism DisorderAplastic AnemiaMyelodysplastic SyndromesChronic LeukemiaLymphomaMultiple MyelomaSolid Tumor
Interventions
RADIATION

Total Body Irradiation 1200 cGy

Total Body Irradiation 1200 cGy in 8 fractions

RADIATION

Total Body Irradiation 200 cGy

Total Body Irradiation 200 cGy in one fraction

DRUG

Cyclophosphamide

50 mg/kg or 60 mg/kg

DRUG

Mesna

50 mg/kg or 60 mg/kg plus 10% loading dose

PROCEDURE

Cord Blood Infusion

Intravenous infusion of cord blood stem cells

DRUG

Busulfan

0.8 mg/kg x 16 doses

DRUG

Fludarabine

30 mg/m2/day x 5 or 40 mg/m2/day x 5

DRUG

Melphalan

140 mg/m2

Trial Locations (1)

14642

RECRUITING

Wilmot Cancer Institute, Rochester

All Listed Sponsors
lead

University of Rochester

OTHER