The Effect of Biofreeze on Post Manipulation Soreness in Patients With Mechanical Neck Pain

The estimated surface area of the average adult's neck is 350cm and the standard dose of Biofreeze® to achieve a clinically significant effect has been sited to be 1ml/200cm2 of skin surface area. Using this data approximately 1.75 ml of the assigned gel was applied to each participant's neck (posterior, anterior, left lateral and right lateral) by the same member of the research team, 5 minutes prior to an independent practitioner performing cervical manipulation on the participant.

control gel with a similar packaging, texture, and scent as Brand X but without the active ingredient of menthol