264
Participants
Start Date
January 31, 2017
Primary Completion Date
February 28, 2019
Study Completion Date
August 31, 2020
Neoadjuvant Chemoradiotherapy
Before surgery, patients in this group receive neoadjuvant chemoradiotherapy. A total dose of 40 Gy is delivered in 20 fractions (5 fractions per week) for 4 weeks. Chemotherapy is delivered concomitantly and composed of four cycles of paclitaxel 50mg per square meter of body-surface area and cisplatin 25mg per square meter of body-surface area weekly at the intervals of radiotherapy. After neoadjuvant therapy of 4-8 weeks, minimally invasive esophagectomy is performed.
Neoadjuvant Chemotherapy
Before surgery, patients in this group receive neoadjuvant chemotherapy. Chemotherapy is delivered and composed of two cycles of paclitaxel 135mg per square meter of body-surface area and cisplatin 75mg per square meter of body-surface area every 4 weeks. After neoadjuvant therapy of 4-8 weeks, minimally invasive esophagectomy is performed.
Minimally Invasive Esophagectomy
After neoadjuvant therapy, patients in groups receive minimally invasive esophagectomy
Shanghai Zhongshan Hospital, Shanghai
Collaborators (1)
Fujian Medical University Union Hospital
OTHER
Tianjin Medical University Cancer Institute and Hospital
OTHER
Ruijin Hospital
OTHER
Shanghai Chest Hospital
OTHER
First Affiliated Hospital of Chongqing Medical University
OTHER
Changzhi Medical College
OTHER
First Affiliated Hospital of Wenzhou Medical University
OTHER
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
OTHER
Peking University Cancer Hospital and Institute
OTHER
Shanghai Zhongshan Hospital
OTHER