535
Participants
Start Date
June 6, 2017
Primary Completion Date
January 12, 2023
Study Completion Date
April 13, 2023
Metformin Hydrochloride
Women randomised to the metformin group will receive metformin 500mg once daily, with the dose titrated upwards every 2 days over 10 days increasing to a maximum of 2500mg Metformin daily (5 tablets) or maximum tolerated dose, in addition to usual care (exercise and MNT), and taken until delivery.
Placebo
Women randomised to the placebo group will receive 1 placebo tablet once daily, with the dose titrated upwards every 2 days over 10 days increasing to a maximum of five placebo tablets daily, in addition to usual care (exercise and MNT), and taken until delivery.
Portiuncula University Hospital, Ballinasloe
University Hospital Galway, Galway
Collaborators (1)
Health Research Board, Ireland
OTHER
HRB Clinical Research Facility Galway
OTHER
University College Hospital Galway
OTHER
Portiuncula University Hospital
UNKNOWN
University Hospital of Limerick
OTHER
University Maternity Hospital Limerick
UNKNOWN
Clinical Research Support Unit, University of Limerick
UNKNOWN
National University of Ireland, Galway, Ireland
OTHER