PrevenTion of Contrast-inducEd nephroAThy With urinE Alkalinization

PHASE3CompletedINTERVENTIONAL
Enrollment

240

Participants

Timeline

Start Date

March 31, 2015

Primary Completion Date

October 30, 2020

Study Completion Date

May 1, 2021

Conditions
Acute Kidney InjuryContrast Media Reaction
Interventions
DRUG

isotonic saline

patients will start hydration with isotonic saline 6 hours before angiography and continue for 12 hours after the procedure.

DRUG

i.v. sodium bicarbonate

patients will start hydration with isotonic saline 6 hours before angiography and continue for 12 hours after the procedure. The patient receives solution of 1.4% sodium bicarbonate (167 mEq/L; 334 mOsm/L) one hours and six hours after procedure.

DRUG

oral sodium bicarbonate

patients will start hydration with isotonic saline 6 hours before angiography and continue for 12 hours after the procedure. One hour before the angiography and 3 hours after patients will receive oral sodium bicarbonate at the dose of 4 g (47.6 mEq) dissolved in 60 mL of water

Trial Locations (1)

66100

Institute of Cardiology - Center of Excellence on Aging, G. d'Annunzio University, Chieti

All Listed Sponsors
lead

G. d'Annunzio University

OTHER

NCT02980003 - PrevenTion of Contrast-inducEd nephroAThy With urinE Alkalinization | Biotech Hunter | Biotech Hunter