JYNNEOS Smallpox Vaccine in Adult Healthcare Personnel at Risk for Mpox in the Democratic Republic of the Congo

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,600

Participants

Timeline

Start Date

February 23, 2017

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Monkeypox Virus Infection
Interventions
BIOLOGICAL

JYNNEOS (Liquid Formulation)

Two doses of attenuated live virus smallpox vaccine (JYNNEOS liquid formulation) administered on days 0 and 28 via subcutaneous injection (deltoid) (1 x 10\^8 Tissue Culture Infectious Dose 50 \[TCID50\] per 0.5 mL). A subset of participants will receive a booster dose.

BIOLOGICAL

JYNNEOS (Lyophilized Formulation)

Two doses of attenuated live virus smallpox vaccine (JYNNEOS lyophilized formulation) administered on days 0 and 28 via subcutaneous injection (deltoid) (1 x 10\^8 Tissue Culture Infectious Dose 50 \[TCID50\] per 0.5 mL). A subset of participants will receive a booster dose.

Trial Locations (1)

Unknown

Tshuapa site, Boende

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Ministry of Public Health, Democratic Republic of the Congo

OTHER_GOV

collaborator

Kinshasa School of Public Health

OTHER

collaborator

Bavarian Nordic

INDUSTRY

lead

Centers for Disease Control and Prevention

FED

NCT02977715 - JYNNEOS Smallpox Vaccine in Adult Healthcare Personnel at Risk for Mpox in the Democratic Republic of the Congo | Biotech Hunter | Biotech Hunter