A Phase Ib Study of LXH254-centric Combinations in NSCLC or Melanoma

PHASE1TerminatedINTERVENTIONAL
Enrollment

241

Participants

Timeline

Start Date

February 24, 2017

Primary Completion Date

April 24, 2024

Study Completion Date

April 24, 2024

Conditions
Non-Small Cell Lung CancerMelanoma
Interventions
DRUG

LXH254

LXH254 will be supplied as tablet for oral use.

DRUG

LTT462

LTT462 will be supplied as hard gelatin capsule for oral use.

DRUG

Trametinib

Trametinib will be supplied as film-coated tablet for oral use

DRUG

Ribociclib

Ribociclib will be supplied in tablets and hard gelatin capsules.

Trial Locations (32)

2145

Novartis Investigative Site, Westmead

3000

Novartis Investigative Site, Melbourne

Novartis Investigative Site, Leuven

10065

Memorial Sloan Kettering Cancer Ctr ., New York

20089

Novartis Investigative Site, Rozzano

20133

Novartis Investigative Site, Milan

20162

Novartis Investigative Site, Milan

28034

Novartis Investigative Site, Madrid

31008

Novartis Investigative Site, Pamplona

37126

Novartis Investigative Site, Verona

37203

Sarah Cannon Research Institute Tennessee Oncology, Nashville

41013

Novartis Investigative Site, Seville

45147

Novartis Investigative Site, Essen

46010

Novartis Investigative Site, Valencia

50937

Novartis Investigative Site, Cologne

60590

Novartis Investigative Site, Frankfurt

69373

Novartis Investigative Site, Lyon

75475

Novartis Investigative Site, Paris

77030

Uni of TX MD Anderson Cancer Cntr, Houston

80131

Novartis Investigative Site, Napoli

92103

University of California San Diego ., San Diego

94143

UCSF Medical Center, San Francisco

94800

Novartis Investigative Site, Villejuif

6423906

Novartis Investigative Site, Tel Aviv

02114

Massachusetts General Hospital SC, Boston

01307

Novartis Investigative Site, Dresden

02 781

Novartis Investigative Site, Warsaw

03080

Novartis Investigative Site, Seoul

06351

Novartis Investigative Site, Seoul

08035

Novartis Investigative Site, Barcelona

08036

Novartis Investigative Site, Barcelona

171 76

Novartis Investigative Site, Stockholm

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY