Interventions for Reading Disabilities in NF1

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

November 30, 2016

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
Neurofibromatosis Type 1Learning DisabilityReading DisabilityNF1
Interventions
DRUG

Lovastatin

Those in the Lovastatin group will receive 20mg of Lovastatin per day for the first two weeks and 40mg of Lovastatin per day starting at week 3 through week 11.

BEHAVIORAL

reading tutoring intervention

After the initial 12 weeks of Lovastatin or placebo, children will return for one week of intensive, one-on-one tutoring intervention (either reading or sham; Visit 2)

DRUG

Placebo Oral Tablet

Those in the placebo group will receive a tablet daily

BEHAVIORAL

"Other Academic sham tutoring"

No reading (sham) tutoring. Children will receive intensive tutoring on a subject other than reading.

Trial Locations (1)

Unknown

Vanderbilt University, Nashville

All Listed Sponsors
collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

lead

Vanderbilt University

OTHER