Interleukin-2 and Pembrolizumab for Metastatic Kidney Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

27

Participants

Timeline

Start Date

April 25, 2017

Primary Completion Date

March 26, 2019

Study Completion Date

October 31, 2025

Conditions
Kidney Cancer
Interventions
DRUG

Pembrolizumab

Pembrolizumab: 200 mg every 3 weeks, 12 doses planned. This is considered the investigational part of the combination. The infusion time is 1 hour.

DRUG

Interleukin-2

Interleukin-2: 8 admissions to hospital, each with 5 doses planned. This is considered the standard part of the combination. The standard interleukin-2 dose is 600,000 international units per kilogram per dose, with a maximum of 66,000,000 (for patients over 110 kg, which is 242 pounds). The dose is usually set at the start of the treatment and not adjusted. The infusion time is 15 minutes.

Trial Locations (1)

33612

H. Lee Moffitt Cancer Center and Research Institute, Tampa

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

Prometheus Laboratories

INDUSTRY

lead

H. Lee Moffitt Cancer Center and Research Institute

OTHER