3
Participants
Start Date
February 20, 2017
Primary Completion Date
October 17, 2017
Study Completion Date
October 17, 2017
Trans-arterial Chemo-Embolization
Trans-Arterial Chemo-Embolization will be performed with Doxorubicin-Eluting-Beads (DEB-TACE). It will be performed in each arm of treatment.
Doxorubicin
Drug-eluting Bead for Trans Arterial Chemo-Embolization will be loaded with Doxorubicin.
Stereotactic Ablative Radiotherapy
"SABR schemes will be adapted according to the CP score and the vicinity of surrounding organs at risk. These are the different schemes proposed in this trial:~48Gy = 3x16Gy BED 124.8Gy ( α/β=10) 50Gy = 5x10Gy BED 100Gy ( α/β=10) 48Gy = 6x8Gy BED 86.4Gy ( α/β=10) 40Gy = 5x8Gy BED 72Gy ( α/β=10)~For patients with Child-Pugh (CP) A cirrhosis : the choice of the scheme will be left to each physician. The highest BED should be favored if dose constraints to the organs at risk are respected.~For patients with CP B cirrhosis : only the latter scheme will be allowed: 40Gy = 5x8Gy."
Institut Jules Bordet/Hôpital Erasme, Brussels
Cliniques Universitaires Saint Luc, Brussels
Centre Hospitalier Universitaire/CHC Saint Joseph, Liège
Clinique et Maternité Sainte Elisabeth/CHU Mont Godinne, Namur
Hôpital de JOLIMONT, Jolimont
Collaborators (1)
Erasme University Hospital
OTHER
Jules Bordet Institute
OTHER
University of Liege
OTHER
Clinique Saint Joseph, Liège
OTHER
Centre Hospitalier Universitaire UCLouvain Namur
OTHER
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
OTHER