Trial of Magrolimab (Hu5F9-G4) in Combination With Rituximab or Rituximab + Chemotherapy in Participants With Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

178

Participants

Timeline

Start Date

November 21, 2016

Primary Completion Date

March 25, 2024

Study Completion Date

March 25, 2024

Conditions
Non Hodgkin Lymphoma
Interventions
DRUG

Magrolimab

Administered intravenously

DRUG

Rituximab

Administered intravenously on Days 8, 15, and 22 during Cycle 1, followed by 1 dose on Day 1 for Cycles 2 through 6, and Day 1 for every other cycle until Cycle 13

DRUG

Gemcitabine

Administered intravenously on Days 11, 23 for Cycle 1 and Days 2 and 15 for Cycles 2 to 4

DRUG

Oxaliplatin

Administered intravenously on Days 11, 23 for Cycle 1 and Days 2 and 15 for Cycles 2 to 4

DRUG

Allopurinol

Administered orally during Cycle 1

Trial Locations (20)

3065

St. Vincent's Hospital Melbourne, Melbourne

4102

Princess Alexandra Hospital, Brisbane

6009

Linear Clinical Research Ltd, Nedlands

19104

Hospital of the University of Pennsylvania, Philadelphia

20892

National Institutes of Health Clinical Center/ National Cancer Institute, Bethesda

28204

Levine Cancer Institute, Charlotte

30912

Georgia Cancer Center at Augusta University, Augusta

35924

University of Alabama At Birmingham (Uab), Birmingham

37203

The Sarah Cannon Research Institute, Nashville

48109

University of Michigan, Ann Arbor

55455

University of Minnesota Medical Center, Fairview, Minneapolis

60637

University of Chicago Medical Center, Chicago

63110

Washington University School of Medicine Siteman Cancer Center, St Louis

73104

Stephenson Cancer Center, Oklahoma City

77030

The University of Texas MD Anderson Cancer Center, Houston

91010

City of Hope National Medical Center, Duarte

94305

Stanford Cancer Center, Stanford

02215

Beth Israel Deaconess Medical Center, Boston

Dana Farber Cancer Institute, Boston

OX3 7LE

The Churchill Hospital, Oxford

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

The Leukemia and Lymphoma Society

OTHER

lead

Gilead Sciences

INDUSTRY