Avelumab In Combination Regimens That Include An Immune Agonist, Epigenetic Modulator, CD20 Antagonist and/or Conventional Chemotherapy in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL)

PHASE3TerminatedINTERVENTIONAL
Enrollment

29

Participants

Timeline

Start Date

December 16, 2016

Primary Completion Date

December 2, 2019

Study Completion Date

December 2, 2019

Conditions
Diffuse Large B-Cell Lymphoma
Interventions
BIOLOGICAL

Avelumab

Investigational fully human anti-PD-L1 monoclonal antibody

BIOLOGICAL

Utomilumab

Investigational, fully human IgG2 CD 137/4-1BB agonist

BIOLOGICAL

Rituximab

CD20-directed cytolytic antibody

OTHER

Azacitidine

Antimetabolite antineoplastic agent and demethylation agent.

DRUG

Bendamustine

Alkylating drug

DRUG

Gemcitabine

Nucleoside analogue

DRUG

Oxaliplatin

Platinum-based drug

Trial Locations (29)

2217

St. George Hospital, Kogarah

3000

UZ Leuven, Leuven

3084

Cancer Clinical Trials Centre, Austin Health, Level 4, Heidelberg

Genesis Care, Heidelberg

3168

Monash Health, Clayton

9000

UZ Gent, Ghent

10003

Hospital San Pedro de Alcantara, Cáceres

11733

North Shore Hematology Oncology Associates, East Setauket

20089

Farmacia Studi Clinici, Rozzano

Istituto Clinico Humanitas, Rozzano

29010

Centro de Investigación Medicina Especializada Sanitaria (CIMES), Málaga

Hospital Universitario Virgen de la Victoria, Málaga

40207

Norton Cancer Institute, Louisville

Norton Diagnostic Center - Dupont, Louisville

Norton Women's and Children's Hospital, Louisville

48109

University of Michigan Health System, Ann Arbor

55905

Mayo Clinic, Rochester

70112

Tulane Medical Center, New Orleans

91010

City of Hope, Duarte

01821

Parexel International, Billerica

30-510

Malopolskie Centrum Medyczne S.C., Krakow

20-090

Centrum Onkologii Ziemi Lubelskiej im. Sw. Jana z Dukli, Lublin

Centrum Onkologii Ziemi Lubelskiej im. Sw. Jana z Dukli Oddzial Hematologiczny, Lublin

30-006

Nzoz McD Voxel Osrodek Pet-Tk-Nmr, Krakow

22-400

NU-MED Centrum Diagnostyki i Terapii Onkologicznej Zamosc Sp. z o.o., Zamość

06351

Samsung Medical Center Clinical Trial Pharmacy, Seoul

Samsung Medical Center, Seoul

M20 4BX

The Christie NHS Foundation Trust, Manchester

The Christie Pathology Partnership, Manchester

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

EMD Serono

INDUSTRY

lead

Pfizer

INDUSTRY