A Study to Determine the Safety of BTP-114 for Treatment in Patients With Advanced Solid Tumors With BRCA Mutations

PHASE1UnknownINTERVENTIONAL
Enrollment

95

Participants

Timeline

Start Date

September 30, 2016

Primary Completion Date

April 30, 2020

Study Completion Date

August 31, 2020

Conditions
Pancreatic NeoplasmsOvarian NeoplasmsBreast NeoplasmsProstatic Neoplasms
Interventions
DRUG

BTP-114

"Part 1 (Escalation) IV treatment of BTP-114 in 21-day cycles. Doses will be increased in sequential cohorts until the maximum tolerated dose is determined which will lead to the recommended phase 2 dose~Part 2 (Expansion) 5 cohorts of patients will be treated at the RP2D of IV BTP-114 in 21-day cycles for the tumor types pancreatic cancer, castration-resistant prostate cancer, ovarian cancer, triple-negative breast cancer and deoxyribonucleic acid (DNA) repair mutation-positive advanced solid tumors."

Trial Locations (8)

34232

Placon Therapeutics Clinical Trial Site, Sarasota

37203

Placon Therapeutics Clinical Trial Site, Nashville

44106

Placon Therapeutics Clinical Trial Site, Cleveland

63110

Placon Therapeutics Clinical Trial Site, St Louis

73104

Placon Therapeutics Clinical Trial Site, Oklahoma City

77030

Placon Therapeutics Clinical Trial Site, Houston

02114

Placon Therapeutics Clinical Trial Site, Boston

02215

Placon Therapeutics Clinical Trial Site, Boston

Sponsors
All Listed Sponsors
lead

Placon Therapeutics

INDUSTRY