Low-dose AZA, Pioglitazone, ATRA Versus Standard-dose AZA in Patients >=60 Years With Refractory AML

PHASE2TerminatedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

April 10, 2017

Primary Completion Date

March 25, 2020

Study Completion Date

March 25, 2020

Conditions
Acute Myeloid Leukemia
Interventions
DRUG

low-dose Azacitidine

Azacitidine 75 mg/d s.c. for 7 days, repeated 28-day treatment cycle

DRUG

Pioglitazone

Pioglitazone 45 mg p.o. continuously from day 1

DRUG

ATRA

ATRA \*45 mg/m² p.o. from day 1 to 28, 15 mg/m² from day 29 continuously; \*this regimen will be chosen for the first dose to be evaluated.

DRUG

standard-dose AZA

Azacitidine 75 mg/m²/d s.c. for 7 days, repeated 28-day treatment cycle

Trial Locations (1)

93053

University Hospital Regensburg, Regensburg

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Anticancer Fund, Belgium

OTHER

collaborator

Celgene

INDUSTRY

lead

University Hospital Regensburg

OTHER