Precision Medicine Offers Belatacept Monotherapy

PHASE4WithdrawnINTERVENTIONAL
0
Timeline

Start Date

February 28, 2019

Primary Completion Date

February 29, 2020

Study Completion Date

December 31, 2022

Conditions
Transplantation
Interventions
DRUG

Belatacept

The transition to belatacept monotherapy and possibly to q 8 weeks administration can be safely done by applying personalized (i.e. precision) medicine. This includes phenotypic analysis of lymphocyte subsets, a quiescent molecular profiling of blood and urine prior to drug withdrawal and immune monitoring with KSORT after stepwise withdrawal of steroids and antiproliferatives. Furthermore, trough PK of belatacept will be measured for conversion to q 8 week therapy for discovering research purposes.

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

University of California, San Francisco

OTHER