Metastatic Colorectal Cancer (RAS-wildtype) After Response to First-line Treatment With FOLFIR Plus Cetuximab

Irinotecan 180 mg/m² iv, 30 - 90 min., day 1, q d15

Folinic acid (racemic) 400 mg/m² iv, 120 min. day 1, q d15

5-FU 400 mg/m² bolus day 1, q d15

5-FU 2400 mg/m² iv over 46 h day 1-2, q d15

cetuximab initially 400 mg/m² as a 120 min. infusion (≤ 5mg/min); subsequently 250 mg/m² iv respectively as a 60 min. infusion (≤ 10mg/min) day 1 + 8

Bevacizumab 7.5 mg/kg BW iv over 30 to 90 minutes: day 1

Capecitabine 1250 mg/m2 2 x day p.o. day 1-14, q d15

160 mg per day (day 1-21) (repeated on day 28)

Irinotecan 125 mg/m² iv, 60 - 90 min. weekly (D1, D8, D15, D22)

Cetuximab initially 400 mg/m² as a 120 min. infusion (≤ 5mg/min); subsequently 250 mg/m² iv respectively as a 60 min. infusion (≤ 10mg/min) weekly (D1, D8, D15, D22, D29, D36)