Compare Apixaban and Vitamin-K Antagonists in Patients With Atrial Fibrillation (AF) and End-Stage Kidney Disease (ESKD)

PHASE3CompletedINTERVENTIONAL
Enrollment

108

Participants

Timeline

Start Date

June 20, 2017

Primary Completion Date

July 31, 2022

Study Completion Date

July 31, 2022

Conditions
Atrial FibrillationEnd-stage Kidney Disease
Interventions
DRUG

Apixaban

Patients will be instructed to take one tablet of 2.5 mg twice daily: one tablet in the morning and one in the evening at approximately the same time every day (with about 12 hours gap) irrespective of the time of dialysis.

DRUG

Phenprocoumon

Subjects in phenprocoumon treatment group will receive phenprocoumon individually adjusted to an INR of 2.0-3.0 as recommended in the appropriate SmPC for AF patients.

Trial Locations (1)

48149

Universitätsklinikum Münster, Münster

Sponsors
All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Pfizer

INDUSTRY

lead

Atrial Fibrillation Network

OTHER