10
Participants
Start Date
December 17, 2018
Primary Completion Date
September 27, 2021
Study Completion Date
February 28, 2037
GAP T cells
"Five different dosing schedules will be evaluated. Three to six patients will be evaluated on each dosing schedule. The following dose levels will be evaluated:~DL1: 1x10\^7/m2~DL2: 3x10\^7/m2~DL3: 1x10\^8/m2~DL4: 3x10\^8/m2~DL5: 1x10\^9/m2~The doses are calculated according to the actual number of GPC3-CAR transduced T cells."
Cytoxan
Cyclophosphamide will be given at a dose of 500 mg/m2/day for 3 days given intravenously.
Fludara
Fludarabine will be given at a dose of 30 mg/m2/day for 3 days given intravenously.
Texas Children's Hospital, Houston
Center for Cell and Gene Therapy, Baylor College of Medicine
OTHER
Cancer Prevention Research Institute of Texas
OTHER
The V Foundation
OTHER
Cookies for Kids' Cancer
OTHER
Curing Kids' Cancer Foundation
OTHER
Baylor College of Medicine
OTHER