Medication-related Osteonecrosis of the Jaw (MRONJ) Registry

Active, not recruitingOBSERVATIONAL
Enrollment

518

Participants

Timeline

Start Date

August 14, 2017

Primary Completion Date

October 13, 2023

Study Completion Date

April 30, 2024

Conditions
Medication-related Osteonecrosis of the JawBisphosphonate-Associated Osteonecrosis of the Jaw
Interventions
PROCEDURE

Conservative treatment

Disinfectant mouth rinses, Antibiotic therapy, Antifungal therapy

PROCEDURE

Surgical treatment

Superficial debridement, Complete removal of necrotic bone, Complete bone resection, When applicable revision and soft tissue coverage

PROCEDURE

Adjuvant non-surgical treatment

Hyperbaric oxygen therapy Pentoxifylline and tocopherol Ozone therapy Low level laser therapy Pain relief Anti-inflammatory treatment Platelet rich plasma Parathyroid hormone and teriparatide Bone morphogenetic protein

Trial Locations (14)

4031

Universitätsspital Basel, Basel

40536

University of Kentucky Chandler Medical Center, Lexington

80337

Ludwig-Maximilians University Munich, Klinik und Poliklinik für Mund-, Kiefer und Gesichtschirurgie, München

00029

Helsinki University Hospital, Helsinki

Unknown

Charité - Universitätsmedizin Berlin, Berlin

Universitätskliniken Eppendorf, Hamburg

Eramus MC, Rotterdam

Hamad Medical Corporation, Doha

Emergency Clinical County Hospital of Constanta, Constanța

University Medical Centre Ljubljana, Ljubljana

Kyungpool National University, Daegu

12 de Octubre University Hospital, Madrid

Luzerner Kantonsspital, Lucerne

Universitätsspital Zürich, Zurich

All Listed Sponsors
collaborator

AOCMF

OTHER

lead

AO Clinical Investigation and Publishing Documentation

OTHER