Anti-mesothelin CAR T Cells for Patients With Recurrent or Metastatic Malignant Tumors

PHASE1UnknownINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

August 31, 2016

Primary Completion Date

August 31, 2018

Study Completion Date

August 31, 2019

Conditions
Mesothelin Positive Tumors
Interventions
BIOLOGICAL

anti-mesothelin CAR T cells

Patients will be received a three-day regimen of chemotherapy consisting of cyclophosphamide aimed to deplete the lymphocytes. 1 to 4 days after lymphodepletion, patients are intravenously infused with anti-mesothelin CAR T cells in a three-day split-dose regimen (day0,10%; day1, 30%; day2, 60%).

Trial Locations (1)

100028

RECRUITING

China Meitan General Hospital, Beijing

Sponsors
All Listed Sponsors
collaborator

Marino Biotechnology Co., Ltd.

INDUSTRY

lead

China Meitan General Hospital

OTHER