Cognitive Remediation for Alcohol Use Disorder and Posttraumatic Stress Disorder

NACompletedINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

January 1, 2015

Primary Completion Date

July 21, 2019

Study Completion Date

July 21, 2019

Conditions
Alcohol Use DisorderPTSDCognitive Dysfunction
Interventions
BEHAVIORAL

Cognitive Training

Participants will complete 22.5 hours of cognitive training exercises over 6-weeks (training 5 times a week) using an app-based program, BrainHQ (BPI/Posit Science, San Francisco). BrainHQ is based on a previous neuroscience-based cognitive training program shown to improve cognition in several different randomized controlled studies with other clinical populations. The investigators will use a suite of BrainHQ exercises designed to target and ameliorate cognitive disruptions in 4 cognitive domains (see main outcome). The investigators will employ basic exercises that focus on increasing processing efficiency in the auditory and visual perceptual and working memory domains, as well as exercises that target impulsivity and cognitive biases. Exercises will be packaged into 4 modules (attention skills, memory skills, executive functioning skills, cognitive control skills) comprised of 4 exercises each. All participants will progress through the same fixed schedule of modules.

BEHAVIORAL

Cognitive training placebo control

Participants will play a rotating set of commercial computer games at the same dose and frequency as the cognitive training. The investigators selected this control activity because it mirrors the game-like properties of the cognitive training and it will be used to control for contact with research personnel and for the non-specific effects of participant motivation and engagement with daily computerized activities. It also allows for a double blind study design. Games from the website Sporcle will be used and an online account can be created for each participant.

Trial Locations (1)

94304-1290

VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto

All Listed Sponsors
lead

VA Office of Research and Development

FED

NCT02929979 - Cognitive Remediation for Alcohol Use Disorder and Posttraumatic Stress Disorder | Biotech Hunter | Biotech Hunter