Impact of Soft Tissue Grafts on Tissue Alterations After Immediate Tooth Replacement

PHASE4CompletedINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

February 28, 2013

Primary Completion Date

December 31, 2013

Study Completion Date

June 30, 2015

Conditions
Tooth SocketDental Implants
Interventions
BIOLOGICAL

Connective tissue graft

A 1.5 mm thick soft tissue graft removed from the palate with determined dimensions. The recipient site was prepared by performing laterally a delicate elevation of the facial tissue avoiding the mesial and distal papilla. The soft tissue graft length was equal to the horizontal distance between the two papillas and its length was set at 6 mm. Soft tissue grafts were placed at the level of the gingival margin and stabilized with simple interrupted sutures.

BIOLOGICAL

Collagen matrix graft

A 15x20 mm collagen matrix trimmed according to determined dimensions. The recipient site was prepared by performing laterally a delicate elevation of the facial tissue avoiding the mesial and distal papilla. The soft tissue graft length was equal to the horizontal distance between the two papillas and its length was set at 6 mm. Soft tissue grafts were placed at the level of the gingival margin and stabilized with simple interrupted sutures.

DEVICE

Immediate implant

A conical implant with a morse-taper connection with moderate roughness implant surface was properly installed in the ideal tridimensional position with its platform placed 4 mm below the facial gingival margin. After tooth extraction and dental implant installation with a torque \> 32 Ncm patients were randomized into three groups (8 patients per group): 1- No soft tissue graft, Control group (CTL); 2- Collagen Matrix group (CM); 3- Connective tissue graft group (CTG).

PROCEDURE

Tooth extraction

Compromised tooth was gently removed and the socket was debrided thoroughly, cleansed and inspected. The socket's palatal and apical bone was sequentially drilled. All surgeries were performed by the same surgeon and were individually planned according to the clinical and tomographic evaluation. Implant diameter was set as 3.5 mm and its length was selected according to the quantity of bone available apically to the fresh alveolar socket.

DEVICE

Immediate restoration

A titanium abutment was installed in the dental implant with manual torque and a prefabricated tooth shell was relined with resin material to fabricate cement or screw retained interim restoration. All interim restorations were installed in infra-occlusion matching the adjacent teeth color and form, with light proximal contacts and presented a subgingival concave contour.

BIOLOGICAL

Bone regeneration

All sites received a non-cross linked collagen membrane and deproteinized bovine bone mineral containing 10% of porcine collagen.

DRUG

Post operative medication

Postoperative instructions were given, antibiotics were prescribed for 7 days (amoxicillin 500 mg t.i.d), analgesics to relieve from pain (Paracetamol 750 mg) and chlorhexidine 0.12% rinse twice a day for 15 days. Complementary, the patients were instructed to avoid chewing in the anterior region and to follow a soft diet.

DEVICE

Definitive prosthesis

Definitive implant-supported restorations were performed 6 months after dental implant placement.

OTHER

No soft tissue graft

No soft tissue graft was used

Trial Locations (1)

14801-903

Araraquara Dental School at the São Paulo State University, Araraquara

All Listed Sponsors
collaborator

Fundação de Amparo à Pesquisa do Estado de São Paulo

OTHER_GOV

collaborator

Conselho Nacional de Desenvolvimento Científico e Tecnológico

OTHER_GOV

lead

São Paulo State University

OTHER

NCT02922075 - Impact of Soft Tissue Grafts on Tissue Alterations After Immediate Tooth Replacement | Biotech Hunter | Biotech Hunter