A Study to Evaluate the Efficacy, Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant Depression

Participant will receive 1 spray of placebo to each nostril at 0 minute, 5 minutes and 10 minutes.

Participant will receive 1 spray of Esketamine to each nostril at 0 minute and placebo at 5 minutes and 10 minutes.

Participant will receive 1 spray of Esketamine to each nostril at 0 minute, 5 minutes and placebo at 10 minutes.

Participant will receive 1 spray of Esketamine to each nostril at 0 minute, 5 minutes and 10 minutes.