Imiquimod Treatment of High-grade CIN

NAUnknownINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

November 30, 2016

Primary Completion Date

July 31, 2018

Study Completion Date

December 31, 2020

Conditions
Cervical Intraepithelial Neoplasia
Interventions
DRUG

Imiquimod

Patients in this group are treated with vaginal imiquimod cream during 16 weeks. A control colposcopy with diagnostic biopsies will be performed after 10 weeks to rule out disease progression. A final colposcopy with diagnostic biopsies will be performed after 20 weeks to evaluate disease efficacy.

PROCEDURE

Large Loop Excision of the Transformation Zone

Patients in this group are treated with LLETZ.

Trial Locations (3)

Unknown

Meander Medical Center, Amersfoort

Erasmus Medical Center, Rotterdam

6202AZ

Maastricht University Medical Center, Maastricht

Sponsors
All Listed Sponsors
collaborator

Clinical Trial Center Maastricht B.V.

OTHER

lead

Maastricht University Medical Center

OTHER