Study of Avelumab With or Without Entinostat in Participants With Advanced Epithelial Ovarian Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

140

Participants

Timeline

Start Date

December 19, 2016

Primary Completion Date

February 21, 2019

Study Completion Date

April 21, 2021

Conditions
Epithelial Ovarian CancerPeritoneal CancerFallopian Tube Cancer
Interventions
DRUG

entinostat

An orally available histone deacetylases inhibitor (HDACi).

DRUG

avelumab

A fully human antibody of the immunoglobulin (Ig) G1 isotype that targets and blocks Programmed death-ligand 1 (PD-L1), the ligand for Programmed cell death protein 1 (PD-1) receptor.

DRUG

Placebo

A pill containing no active drug ingredient.

Trial Locations (12)

10065

Memorial Sloan Kettering Cancer Center, New York

19107

University of Pennsylvania, Philadelphia

21204

Greater Baltimore Medical Center, Baltimore

21287

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore

22908

University of Virginia, Charlottesville

33401

Florida Cancer Specialist East Region (SCRI Affiliate), West Palm Beach

33612

H. Lee Moffitt Cancer Center and Research, Tampa

37204

Sarah Cannon Research Institute, Nashville

60637

University of Chicago, Chicago

64131

HCA Midwest Health (SCRI Affiliate), Kansas City

02114

Massachusetts General Hospital, Boston

02215

Dana Farber Cancer Institute, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Merck KGaA, Darmstadt, Germany

INDUSTRY

collaborator

Pfizer

INDUSTRY

lead

Syndax Pharmaceuticals

INDUSTRY