Ibrutinib Plus Venetoclax in Subjects With Treatment-naive Chronic Lymphocytic Leukemia /Small Lymphocytic Lymphoma (CLL/SLL)

PHASE2CompletedINTERVENTIONAL
Enrollment

323

Participants

Timeline

Start Date

September 28, 2016

Primary Completion Date

November 12, 2020

Study Completion Date

March 27, 2024

Conditions
LeukemiaChronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Interventions
DRUG

ibrutinib

ibrutinib administered orally once daily (three 140 mg capsules)

DRUG

venetoclax

venetoclax tablets will be administered orally once daily starting with a 5 week ramp up of 20 mg, 50 mg, 100 mg, 200 mg and 400 mg. After ramp up, venetoclax will be administered at 400 mg.

DRUG

Placebo

placebo capsules to match ibrutinib administered orally once daily

Trial Locations (46)

2025

Middlemore Hospital /ID# 1142-0662, Otahuhu

2217

St George Hospital /ID# 1142-0654, Kogarah

3002

Peter MacCallum Cancer Centre-East Melbourne /ID# 1142-0633, East Melbourne

3065

St Vincent's Hospital Melbourne /ID# 1142-0501, Fitzroy

3084

Austin Health /ID# 1142-0170, Heidelberg

3168

Monash Medical Centre /ID# 1142-0556, Clayton

3199

Frankston Hospital /ID# 1142-0715, Frankston

4414

Palmerston North Hospital /ID# 1142-0585, Palmerston North

5042

Flinders Medical Centre /ID# 1142-0163, Bedford Park

8011

Christchurch Hospital /ID# 1142-0589, Christchurch

10021

New York Presbyterian Hospital/Weill Cornell Med College /ID# 1142-0200, New York

11042

Northwell Health/Long Island Jewish Hospital /ID# 1142-0350, New Hyde Park

16132

Ospedale Policlinico San Martino /ID# 1142-0903, Genova

18014

Hospital Universitario Virgen de las Nieves /ID# 1142-1196, Granada

19104

University of Pennsylvania /ID# 1142-0069, Philadelphia

20132

Ospedale San Raffaele IRCCS /ID# 1142-0523, Milan

20162

ASST Grande Ospedale Metropolitano Niguarda /ID# 1142-0581, Milan

28034

Hospital Universitario Ramon y Cajal /ID# 1142-0874, Madrid

28041

Hospital Universitario 12 de Octubre /ID# 1142-0864, Madrid

28100

Azienda Ospedaliero Universitaria Maggiore della Carita di Novara /ID# 1142-0582, Novara

28203

Charlotte-Mecklenberg Hospital, Carolinas Healthcare System, Levine Cancer Inst /ID# 1142-0733, Charlotte

28222

Hospital Universitario Puerta de Hierro, Majadahonda /ID# 1142-0536, Majadahonda

29121

Azienda USL di Piacenza - Ospedale Guglielmo da Saliceto /ID# 1142-1182, Piacenza

31008

Complejo Hospitalario de Navarra /ID# 1142-1197, Pamplona

35128

Azienda Ospedaliera di Padova /ID# 1142-1175, Padua

37007

Hospital Clinico Universitario de Salamanca /ID# 1142-0790, Salamanca

40202

Norton Cancer Center /ID# 1142-0071, Louisville

41124

Azienda Ospedaliero-Universitaria di Modena /ID# 1142-0524, Modena

44195

Cleveland Clinic Foundation /ID# 1142-0739, Cleveland

77030

MD Anderson Cancer Center /ID# 1142-0032, Houston

91010

City of Hope /ID# 1142-0047, Duarte

92093

Moores Cancer Center at UC San Diego /ID# 1142-0241, La Jolla

98104

Swedish Cancer Institute /ID# 1142-0114, Seattle

92868-3201

UC Irvine Medical Center - Chao Family Comprehensive Cancer Center /ID# 1142-0008, Orange

08901

Rutgers Cancer Institute of New Jersey /ID# 1142-1193, New Brunswick

14642-0001

University of Rochester Cancer Center /ID# 1142-0127, Rochester

37404-1108

Tennessee Oncology - Chattanooga /ID# 1142-0123, Chattanooga

0622

North Shore Hospital /ID# 1142-0663, Auckland

30-510

Malopolskie Centrum Medyczne /ID# 1142-0364, Krakow

20-081

Duplicate_Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie /ID# 1142-0590, Lublin

36-200

Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im. ks. B. /ID# 1142-0592, Brzozów

80-952

Samodzielny Publiczny Szpital Klinczny Nr-1- Akademickie Cenrum Klinic /ID# 1142-0529, Gdansk

93-510

Medical Univ. of Lodz and Copernicus Memorial Hospital /ID# 1142-0531, Lodz

08907

Hospital Duran i Reynals /ID# 1142-0604, L'Hospitalet de Llobregat

08036

Hospital Clinic de Barcelona /ID# 1142-0533, Barcelona

08041

Hospital Santa Creu i Sant Pau /ID# 1142-0535, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Janssen Research & Development, LLC

INDUSTRY

lead

Pharmacyclics LLC.

INDUSTRY