Efficacy and Safety of Nilotinib in Patients With a Chronic Disease of the Graft Against the Host

PHASE2CompletedINTERVENTIONAL
Enrollment

65

Participants

Timeline

Start Date

December 24, 2012

Primary Completion Date

July 26, 2017

Study Completion Date

July 26, 2017

Conditions
Graft Versus Host Disease
Interventions
DRUG

Imatinib Mesylate and Nilotinib

"For patients under Imatinib Mesylate: the total length of follow up period for those patients will be for 52 weeks following IM treatment, with a follow up at weeks IM4, IM8, IM12, IM26, IM38 and IM52.~For patients requiring a salvage phase: after the switch for nilotinib, the total length of follow up period for this phase will be for 52 weeks following nilotinib treatment, with a follow up at weeks nilo4, nilo8, nilo12, nilo26, nilo38 and nilo52."

Trial Locations (22)

59037

Diseases of Blood Service HURIEZ hospital CHRU de LILLE, Lille

Unknown

CHU Sart Tilman, Liège

CHU d'Amiens, Amiens

CHU d'Angers, Angers

CHU Besançon, Besançon

CHU Bordeaux, Bordeaux

Hopital Morvan, Brest

CHU Clémenceau, Caen

HIA de Percy, Clamart

CHU de Clermont Ferrand, Clermont-Ferrand

CHU Grenoble, Grenoble

Centre hospitalier et régional de Lille, Lille

CHU de Lyon, Lyon

Institut Paoli Calmettes, Marseille

Hôpital Saint Eloi, Montpellier

CHU Hotel Dieu, Nantes

CHU de Nice, Nice

Hopital NECKER, Paris

Hôpital pitié Salpetrière, Paris

Centre Henri Becquerel, Rouen

CHU de STRASBOURG, Strasbourg

CHU Purpan, Toulouse

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis

INDUSTRY

lead

University Hospital, Lille

OTHER