Study of Tazemetostat in Newly Diagnosed Diffuse Large B Cell and Follicular Lymphoma Patients Treated by Chemiotherapy

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

214

Participants

Timeline

Start Date

October 31, 2016

Primary Completion Date

January 31, 2023

Study Completion Date

April 30, 2026

Conditions
LymphomaDLBCLFollicular Lymphoma
Interventions
DRUG

Tazemetostat

Tablets 200 mg, to be administrated per os

DRUG

Rituximab

375 mg/m²/dose, D1

DRUG

Cyclophosphamide

750 mg/m²/dose, D1

DRUG

Vincristine

1.4 mg/m²/dose (max 2 mg), D1

DRUG

Doxorubicin

50 mg/m²/dose, D1

DRUG

Prednisolone

40 mg/m2 in the morning D1 to D5

Trial Locations (31)

76000

Centre Henri Becquerel, Rouen

Unknown

Institut Jules Bordet, Brussels

CHU de Liege, Liège

CHRU Mont Godinne, Yvoir

Centre Hospitalier Victor Dupouy, Argenteuil

CH d'Avignon - Hôpital Henri Dufaut, Avignon

CHU de Besançon - Hôpital Jean Minjoz, Besançon

Polyclinique Bordeaux Nord Aquitaine, Bordeaux

CH de Chambéry, Chambéry

CHU d'Estaing, Clermont-Ferrand

APHP - Hopital Henri Mondor, Créteil

CHU de Dijon, Dijon

CHU Grenoble, Grenoble

CH Départemental de Vendée, La Roche-sur-Yon

CHRU Lille - Hôpital Claude Huriez, Lille

Chu de Limoges - Hopital Dupuytren, Limoges

Centre Leon Berard, Lyon

Institut Paoli Calmette, Marseille

CHU de Montpellier - Hôpital Saint-Eloi, Montpellier

CHU de Nantes - Hôtel Dieu, Nantes

APHP - Hôpital de la Pitié Salpetrière, Paris

APHP - Hôpital Saint Louis, Paris

CH de Perpigan, Perpignan

CHU Lyon Sud, Pierre-Bénite

Chu de Poitiers - Hopital de Miletrie, Poitiers

CHU de Rennes - Hôpital Pontchaillou, Rennes

Centre Rene Hugenin, Saint-Cloud

Institut de cancérologie de la Loire, Saint-Priest-en-Jarez

CHRU de Strasbourg, Strasbourg

Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse

Institut Gustave Roussy, Villejuif

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Epizyme, Inc.

INDUSTRY

lead

The Lymphoma Academic Research Organisation

OTHER