Study Of Ruxolitinib (INCB018424) With Preoperative Chemotherapy For Triple Negative Inflammatory Breast Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

January 24, 2018

Primary Completion Date

December 31, 2022

Study Completion Date

December 31, 2025

Conditions
Inflammatory Breast Cancer (IBC)
Interventions
DRUG

Ruxolitinib

15 or 20 mg, twice daily by mouth. The run-in part of ruxolitinib lasts 7 days; The treatment of ruxolitinib part lasts 12 weeks.

DRUG

Paclitaxel

80 mg/m2, IV (in the vein) weekly for 12 weeks.

DRUG

Doxorubicin

60 mg/m2, IV (in the vein) every 14 days for 4 doses.

DRUG

Cyclophosphamide

600 mg/m2, IV (in the vein) every 14 days for 4 doses.

Trial Locations (4)

27710

Duke University Medical Center, Durham

55905

Mayo Clinic, Rochester

77030

MD Anderson Cancer Center, Houston

02215

Dana-Farber Cancer Institute, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Incyte Corporation

INDUSTRY

lead

Dana-Farber Cancer Institute

OTHER

NCT02876302 - Study Of Ruxolitinib (INCB018424) With Preoperative Chemotherapy For Triple Negative Inflammatory Breast Cancer | Biotech Hunter | Biotech Hunter