Study of Effects of Sacubitril/Valsartan vs. Enalapril on Aortic Stiffness in Patients With Mild to Moderate HF With Reduced Ejection Fraction

PHASE4CompletedINTERVENTIONAL
Enrollment

465

Participants

Timeline

Start Date

August 17, 2016

Primary Completion Date

December 13, 2018

Study Completion Date

January 26, 2019

Conditions
Heart Failure and Reduced Ejection Fraction
Interventions
DRUG

LCZ696 (sacubitril/valsartan)

24/26mg, 49/51mg and 97/103mg oral, tablets.

DRUG

Enalapril

2.5mg, 5mg, and 10mg, oral, tablets

DRUG

Placebo of Enalapril

matching placebo (2.5mg, 5mg and 10mg) oral, tablets

DRUG

Placebo of LCZ696

matching placebo (24/26mg, 49/51mg and 97/103mg) oral, tablets

Trial Locations (81)

10469

Novartis Investigative Site, The Bronx

11042

Novartis Investigative Site, Lake Success

11422

Novartis Investigative Site, Rosedale

14215

Novartis Investigative Site, Buffalo

19067

Novartis Investigative Site, Yardley

19713

Novartis Investigative Site, Newark

21237

Novartis Investigative Site, Baltimore

23219

Novartis Investigative Site, Richmond

27834

Novartis Investigative Site, Greenville

28227

Novartis Investigative Site, Charlotte

28645

Novartis Investigative Site, Lenoir

30513

Novartis Investigative Site, Blue Ridge

30606

Novartis Investigative Site, Athens

30912

Novartis Investigative Site, Augusta

31024

Novartis Investigative Site, Eatonton

31201

Novartis Investigative Site, Macon

32086

Novartis Investigative Site, Saint Augustine

32117

Novartis Investigative Site, Daytona Beach

32223

Novartis Investigative Site, Jacksonville

33012

Novartis Investigative Site, Hialeah

33125

Novartis Investigative Site, Miami

33126

Novartis Investigative Site, Miami

33133

Novartis Investigative Site, Miami

33134

Novartis Investigative Site, Coral Gables

33135

Novartis Investigative Site, Miami

33144

Novartis Investigative Site, Miami

33155

Novartis Investigative Site, Miami

33165

Novartis Investigative Site, Miami

33166

Novartis Investigative Site, Doral

Novartis Investigative Site, Miami

33176

Novartis Investigative Site, Miami

33180

Novartis Investigative Site, Aventura

33312

Novartis Investigative Site, Fort Lauderdale

33458

Novartis Investigative Site, Jupiter

33462

Novartis Investigative Site, Atlantis

34102

Novartis Investigative Site, Naples

34209

Novartis Investigative Site, Bradenton

34452

Novartis Investigative Site, Inverness

38301

Novartis Investigative Site, Jackson

42303

Novartis Investigative Site, Owensboro

48604

Novartis Investigative Site, Saginaw

48867

Novartis Investigative Site, Owosso

49707

Novartis Investigative Site, Alpena

54220

Novartis Investigative Site, Manitowoc

60031

Novartis Investigative Site, Gurnee

62208

Novartis Investigative Site, Fairview Heights

66209

Novartis Investigative Site, Overland Park

68131

Novartis Investigative Site, Omaha

68506

Novartis Investigative Site, Lincoln

70458

Novartis Investigative Site, Slidell

70535

Novartis Investigative Site, Eunice

70808

Novartis Investigative Site, Baton Rouge

71055

Novartis Investigative Site, Minden

71201

Novartis Investigative Site, Monroe

72202

Novartis Investigative Site, Little Rock

75069

Novartis Investigative Site, McKinney

75071

Novartis Investigative Site, McKinney

75092

Novartis Investigative Site, Sherman

77094

Novartis Investigative Site, Houston

77375

Novartis Investigative Site, Tomball

77598

Novartis Investigative Site, Webster

83814

Novartis Investigative Site, Coeur d'Alene

89128

Novartis Investigative Site, Las Vegas

90211

Novartis Investigative Site, Beverly Hills

91325

Novartis Investigative Site, Northridge

91405

Novartis Investigative Site, Van Nuys

92648

Novartis Investigative Site, Huntington Beach

92663

Novartis Investigative Site, Newport Beach

92704

Novartis Investigative Site, Santa Ana

99204

Novartis Investigative Site, Spokane

99352

Novartis Investigative Site, Richland

35294-0006

Novartis Investigative Site, Birmingham

06830

Novartis Investigative Site, Greenwich

06851

Novartis Investigative Site, Norwalk

06905

Novartis Investigative Site, Stamford

06611

Novartis Investigative Site, Trumbull

08844

Novartis Investigative Site, Hillsborough

07036

Novartis Investigative Site, Linden

07726

Novartis Investigative Site, Manalapan

07046

Novartis Investigative Site, Mountain Lakes

79106-4165

Novartis Investigative Site, Amarillo

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY