Safety and Efficacy Study of GL-0817 (With Cyclophosphamide) for the Prevention of Recurrence of Squamous Cell Carcinoma of the Oral Cavity

PHASE2CompletedINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

March 30, 2017

Primary Completion Date

May 17, 2021

Study Completion Date

May 25, 2021

Conditions
Squamous Cell Carcinoma of the Oral Cavity
Interventions
DRUG

GL-0817

GL-0817, IV at the dose 1.5 mg will be administered 3 times at 3-week intervals followed by 7 doses at 3-month intervals beginning at the Week 18 visit

DRUG

Hiltonol

Hiltonol will be administered intramuscularly at the dose of 1.4 mg as adjuvant to GL0817, 3 times at 3-week intervals followed by 7 doses at 3-month intervals beginning at the Week 18 visit

DRUG

Sargramostim

Sargramostim will be administered intramuscularly at the dose of 100 μg/m2, as adjuvant to GL0817, 3 times at 3-week intervals followed by 7 doses at 3-month intervals beginning at the Week 18 visit

DRUG

cyclophosphamide

cyclophosphamide will be administered IV at a dose of 200 mg/m2 (maximum dose 400 mg) one day prior to first three vaccinations of GL0817 with adjuvants

DRUG

Placebo

Placebo (normal saline) will be administered as per the schedule of cyclophosphamide and GL0817/adjuvants administration

Trial Locations (33)

21201

University of Maryland Greenebaum Cancer Center, Baltimore

Unknown

National Institute of Oncology, Budapest

Semmelweis University, Budapest

University of Debrecen Clinical Center, Debrecen

Bacs-Kiskun County Teaching Hospital, Kecskemét

Medical Center of the University of Pecs, Pécs

Oncology Center of Prof. Franciszek Lukaszczyk in Bydgoszcz, Bydgoszcz

Swietokrzyskie Oncology Center in Kielce, Kielce

Clinical Oncology Center, Omsk

Rostov Oncology Research Institute, Rostov-on-Don

Leningrad Regional Oncology Center, Saint Petersburg

Oncology Center of Moskovskiy District, Saint Petersburg

Ogarev Mordovia State University, Saransk

Clinical Hospital #1, Sterlitamak

Republican Clinical Oncology Center, Ufa

Regional Clinical Oncology Hospital, Yaroslavl

Institute of Oncology and Radiology of Serbia, Belgrade

Military Medical Academy, Clinic of Maxillofacial Surgery, Belgrade

Oncology Institute of Vojvodina (IOV), Clinic of Medical Oncology, Kamenitz

University Hospital Vall d'Hebron (HUVH), Barcelona

University Hospital La Paz, Madrid

Parc Tauli Health Corporation, Sabadell

Cherkasy Regional Oncology Center, Cherkasy

Chernihiv Regional Oncology Center, Chernihiv

Dnipropetrovsk I.I. Mechnykov Regional Clinical Hospital, Dnipro

Ivano-Frankivsk Regional Oncology Center, Ivano-Frankivsk

"Communal Non-profit enterprise Regional Center of Oncology", Kharkiv

Kyiv Regional Oncology Center, Kyiv

Lviv Regional Clinical Hospital, Lviv

Odesa Regional Oncology Center, Odesa

Poltava Regional Clinical Oncology Center, Poltava

Sumy Regional Clinical Oncology Center, Sumy

Podillia Regional Oncology Center, Vinnytsia

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gliknik Inc.

INDUSTRY