Dociparstat Sodium (CX-01) Combined With Standard Induction Therapy for Newly Diagnosed Acute Myeloid Leukemia

PHASE2CompletedINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

August 31, 2016

Primary Completion Date

June 30, 2019

Study Completion Date

June 30, 2019

Conditions
Acute Myeloid Leukemia
Interventions
DRUG

Dociparstat sodium

Subjects received 4 mg/kg dociparstat intravenous (IV) bolus followed by doses of 0.125 or 0.25 mg/kg/hr dociparstat given on Days 1 through 7 with standard induction therapy, on Days 1 through 5 or 7 with standard re-induction therapy, and on Days 1, 3, and 5 with standard consolidation therapy.

DRUG

Idarubicin

Subjects received 12 mg/m2/day idarubicin by slow (10 to 15 minutes) intravenous (IV) injection daily on Days 1, 2 and 3 of induction therapy, and on Days 1 and 2 of re-induction therapy.

DRUG

Cytarabine

Subjects received 100 mg/m2/day cytarabine by continuous intravenous (IV) infusion on Days 1 through 7 of induction therapy and on Days 1 through 5 of re-induction therapy. During consolidation therapy, subjected received 1.0 g/m2 cytarabine IV infusion given over 3 hours every 12 hours on Days 1, 3, and 5.

Trial Locations (23)

10467

Montefiore Medical Center, The Bronx

11042

Northwell Health, Monter Cancer Center, Lake Success

20037

George Washington University, Washington D.C.

29425

Medical University of South Carolina, Charleston

37203

Tennessee Oncology/Sarah Cannon Research Institute, Nashville

40207

Norton Cancer Institute, Louisville

45267

University of Cincinnati, Cincinnati

46237

Franciscan St. Francis Health, Indianapolis

48201

Karmanos Cancer Institute, Detroit

51101

June E. Nylen Cancer Center, Sioux City

55407

Allina Health - Virginia Piper Cancer Institute, Minneapolis

57105

Avera Cancer Institute, Sioux Falls

63110

Washington University School of Medicine in St. Louis, St Louis

70112

Tulane University/Tulane Cancer Center, New Orleans

75246

Baylor Research Institute/Baylor Sammons Cancer Center/Baylor University Medical Center, Dallas

78229

Methodist Healthcare System of San Antonio, San Antonio

80218

Colorado Blood Cancer Institute, Denver

84112

Huntsman Cancer Institute, Salt Lake City

84143

LDS Hospital, Salt Lake City

87131

New Mexico Cancer Care Alliance, Albuquerque

92093

University of California, San Diego, Moores Cancer Center, La Jolla

97239

Oregon Health & Science University Knight Cancer Institute, Portland

02903

Rhode Island Hospital, Providence

Sponsors
All Listed Sponsors
lead

Jazz Pharmaceuticals

INDUSTRY