T Lymphocytes (LT) Expressing iCASP9 and ΔCD19 in Allogeneic Haematopoietic Transplantation.

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

2

Participants

Timeline

Start Date

April 10, 2019

Primary Completion Date

December 26, 2021

Study Completion Date

December 26, 2021

Conditions
Graft Versus Host DiseaseHematological Malignancies
Interventions
DRUG

T lymphocytes iCASP9 ΔCD19

Intravenous injection of the T lymphocytes armed with the iCASP9 suicide gene

DRUG

Dimerizer drug AP1903

"AP1903 drug will be administrated at a dose of 0.4 mg/kg by intravenous route in the two following cases:~* Acute Grade ≥II or symptomatic Grade I GvHD justifying systemic immunosuppression therapy;~* Grade ≥3 toxicity attributable to GMC."

Trial Locations (1)

25000

CHU Jean Minjoz, Besançon

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Etablissement Français du Sang

OTHER

collaborator

Bellicum Pharmaceuticals

INDUSTRY

lead

Centre Hospitalier Universitaire de Besancon

OTHER

NCT02849886 - T Lymphocytes (LT) Expressing iCASP9 and ΔCD19 in Allogeneic Haematopoietic Transplantation. | Biotech Hunter | Biotech Hunter