Autologous CD19 CAR T Cells in Relapsed or Refractory B-cell Lymphoma

PHASE1UnknownINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

June 30, 2016

Primary Completion Date

February 28, 2018

Study Completion Date

August 31, 2019

Conditions
B-cell Lymphoma
Interventions
BIOLOGICAL

autologous anti-CD19 CAR T cells

Patients will receive a three-day regimen of chemotherapy consisting of fludarabine and cyclophosphamide aimed to deplete the lymphocytes. Four days after lymphodepletion, patients are intravenously infused autologous anti-CD19 CAR T cells. A prescribed CAR T cell dose will be intravenously infused to patient in a three-day split-dose regimen (day0,30%; day1, 30%; day2, 40%).

Trial Locations (1)

100142

Peking University Cancer Hospital, Beijing

Sponsors
All Listed Sponsors
collaborator

Marino Biotechnology Co., Ltd.

INDUSTRY

lead

Peking University

OTHER