Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

250

Participants

Timeline

Start Date

February 8, 2017

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Acute Kidney Injury
Interventions
DRUG

Nitric Oxide

Inhaled nitric oxide will be administered in a final concentration of 80 ppm. The treatment will begin at the onset of the cardiopulmonary bypass until to 24h after Intensive Care Unit (ICU) admission, including 2-4 hours of weaning from nitric oxide and careful hemodynamics monitoring.

OTHER

Placebo

This is the placebo group. Nitrogen will be added instead of nitric oxide.

Trial Locations (1)

02114

Massachusetts General Hospital, Boston

All Listed Sponsors
collaborator

Ichinose, Fumito, M.D., Ph.D., Massachusetts General Hospital

UNKNOWN

collaborator

Kenneth, Shelton, M.D., Massachusetts General Hospital

UNKNOWN

collaborator

Kacmarek, Robert M., Ph.D., Massachusetts General Hospital

UNKNOWN

collaborator

Sundt, Thoralf M., M.D., Massachusetts General Hospital

UNKNOWN

collaborator

Villavicencio-Theoduloz, Mauricio A., M.D., Massachusetts General Hospital

UNKNOWN

collaborator

Thompson, Boyd Taylor, M.D., Massachusetts General Hospital

UNKNOWN

collaborator

Bonventre, Joseph V., M.D., Brigham Women Hospital

UNKNOWN

collaborator

Shann, Kenneth G., Massachusetts General Hospital

UNKNOWN

collaborator

Zapol, Warren M., M.D.

INDIV

collaborator

Marrazzo, Francesco, M.D., Massachusetts General Hospital

UNKNOWN

collaborator

Spina, Stefano, M.D., Massachusetts General Hospital

UNKNOWN

collaborator

Zadek, Francesco, M.D., Massachusetts General Hospital

UNKNOWN

collaborator

Rezoagli, Emanuele, M.D., Massachusetts General Hospital

UNKNOWN

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Massachusetts General Hospital

OTHER