An Efficacy, Safety, and Tolerability Study Comparing Dolutegravir (DTG) Plus Lamivudine (3TC) With Dolutegravir Plus Tenofovir/Emtricitabine in Treatment naïve HIV Infected Participants (Gemini 2)

PHASE3CompletedINTERVENTIONAL
Enrollment

722

Participants

Timeline

Start Date

July 18, 2016

Primary Completion Date

April 4, 2018

Study Completion Date

June 29, 2022

Conditions
Infection, Human Immunodeficiency VirusHIV Infections
Interventions
DRUG

Dolutegravir (DTG)

DTG is available as 50 mg white, round, biconvex, film coated tablet debossed on one side with 'SV 572' and on the other side with '50'. The tablets are packaged into high density polyethylene (HDPE) bottles with induction seals and child resistant closures. Each 45 ml bottle contains 30 tablets and a desiccant. DTG 50 mg tablet will be orally administered once daily with or without food upto 148 weeks.

DRUG

Lamivudine (3TC)

Lamivudine is available as swedish orange, 'AA' sized elongated double blind HPMC capsules containing 300 mg lamivudine to visually match overencapsulated TDF/FTC FDC tablet. The capsules are packaged into HDPE bottles with induction seals and child resistant closures. Each 150 mL bottle contains 30 capsules and a desiccant. Overencapsulated 3TC 300 mg tablet will be orally administered once daily with or without food upto 96 weeks. From Week 96 to Week 148, lamivudine will be dispensed as 300 mg white, diamond shaped, scored, film coated tablets debossed with 'GX CJ7' on both sides, packed in over labelled HDPE bottles with child-resistant closures each containing 30 tablets.

DRUG

Tenofovir disoproxil fumarate/Emtricitabine (TDF/FTC FDC)

Tenofovir disoproxil fumarate and Emtricitabine are available as swedish orange, 'AA' sized elongated double blind HPMC capsules containing 300 mg TDF and 200 mg FTC to visually match overencapsulated 3TC tablet. The capsules are packaged into HDPE bottles with induction seals and child resistant closures. Each 150 mL bottle contains 30 capsules and a desiccant. Overencapsulated tenofovir disoproxil fumarate/emtricitabine tablet will be orally administered once daily with or without food upto 96 weeks. From Week 96 to Week 148, tenofovir disoproxil fumarate/emtricitabine will be dispensed as 300/200 mg white, blue, capsule shaped, film coated tablets debossed with 'GILEAD' on one side and '701' on another side, packed in overlabelled HDPE bottles with polypropylene childresistant closures each containing 30 tablets and a desiccant.

Trial Locations (105)

1

GSK Investigational Site, Lima

220

GSK Investigational Site, New Taipei City

330

GSK Investigational Site, Taoyuan District

704

GSK Investigational Site, Tainan City

807

GSK Investigational Site, Kaohsiung City

813

GSK Investigational Site, Kaohsiung City

1090

GSK Investigational Site, Brussels

2010

GSK Investigational Site, Darlinghurst

2150

GSK Investigational Site, Parramatta

3010

GSK Investigational Site, Bern

3068

GSK Investigational Site, Fitzroy North

3181

GSK Investigational Site, Prahran

5000

GSK Investigational Site, Córdoba

6042

GSK Investigational Site, Lodelinsart

8091

GSK Investigational Site, Zurich

9000

GSK Investigational Site, Ghent

10149

GSK Investigational Site, Turin

11490

GSK Investigational Site, Taipei

14000

GSK Investigational Site, México

16128

GSK Investigational Site, Genoa

18014

GSK Investigational Site, Granada

20005

GSK Investigational Site, Washington D.C.

20099

GSK Investigational Site, Hamburg

20142

GSK Investigational Site, Milan

20157

GSK Investigational Site, Milan

20162

GSK Investigational Site, Milan

20900

GSK Investigational Site, Monza

24128

GSK Investigational Site, Bergamo

28006

GSK Investigational Site, Madrid

28040

GSK Investigational Site, Marid

28041

GSK Investigational Site, Madrid

28046

GSK Investigational Site, Madrid

28922

GSK Investigational Site, Alcorcón

29010

GSK Investigational Site, Málaga

30033

GSK Investigational Site, Decatur

30303

GSK Investigational Site, Bucharest

31401

GSK Investigational Site, Savannah

32803

GSK Investigational Site, Orlando

33133

GSK Investigational Site, Miami

33136

GSK Investigational Site, Miami

33407

GSK Investigational Site, West Palm Beach

34982

GSK Investigational Site, Ft. Pierce

41013

GSK Investigational Site, Seville

41100

GSK Investigational Site, Modena

44280

GSK Investigational Site, Guadalajara

46010

GSK Investigational Site, Valencia

46026

GSK Investigational Site, Valencia

48072

GSK Investigational Site, Berkley

50937

GSK Investigational Site, Cologne

53127

GSK Investigational Site, Bonn

60590

GSK Investigational Site, Frankfurt am Main

60612

GSK Investigational Site, Chicago

63139

GSK Investigational Site, St Louis

69317

GSK Investigational Site, Lyon

75246

GSK Investigational Site, Dallas

75970

GSK Investigational Site, Paris

76104

GSK Investigational Site, Fort Worth

77009

GSK Investigational Site, Houston

77098

GSK Investigational Site, Houston

78705

GSK Investigational Site, Austin

80045

GSK Investigational Site, Aurora

81675

GSK Investigational Site, München

90069

GSK Investigational Site, Los Angeles

93009

GSK Investigational Site, Bobigny

94109

GSK Investigational Site, San Francisco

94577

GSK Investigational Site, San Leandro

95825

GSK Investigational Site, Sacramento

190103

GSK Investigational Site, St.Peterburg

193167

GSK Investigational Site, Saint Petersburg

350015

GSK Investigational Site, Krasnodar

420061

GSK Investigational Site, Kazan'

426067

GSK Investigational Site, Izhevsk

650056

GSK Investigational Site, Kemerovo

700116

GSK Investigational Site, Iași

35294-3300

GSK Investigational Site, Birmingham

08844

GSK Investigational Site, Hillsborough

07102

GSK Investigational Site, Newark

45267-0405

GSK Investigational Site, Cincinnati

S2000PBJ

GSK Investigational Site, Rosario

C1221ADC

GSK Investigational Site, Buenos Aires

C1425 AWK

GSK Investigational Site, Buenos Aires

C1426ABP

GSK Investigational Site, Buenos Aires

Prahran 3181

GSK Investigational Site, Melbourne

V6Z 2C7

GSK Investigational Site, Vancouver

M5G 2N2

GSK Investigational Site, Toronto

H4A 3J1

GSK Investigational Site, Montreal

03720

GSK Investigational Site, Distrito Federal

Callao 2

GSK Investigational Site, Lima

Lima 13

GSK Investigational Site, Lima

85-030

GSK Investigational Site, Bydgoszcz

2720-276

GSK Investigational Site, Amadora

1349-019

GSK Investigational Site, Lisbon

4200-319

GSK Investigational Site, Porto

021105

GSK Investigational Site, Bucharest

08003

GSK Investigational Site, Barcelona

08035

GSK Investigational Site, Barcelona

08036

GSK Investigational Site, Barcelona

CH-1205

GSK Investigational Site, Geneva

SE18 4QH

GSK Investigational Site, Woolwich, London

BN2 5BE

GSK Investigational Site, Brighton

L69 3GE

GSK Investigational Site, Liverpool

E1 1BB

GSK Investigational Site, London

NW3 2QG

GSK Investigational Site, London

SE13 6LR

GSK Investigational Site, London

M13 0FH

GSK Investigational Site, Manchester

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

GlaxoSmithKline

INDUSTRY

lead

ViiV Healthcare

INDUSTRY