An Efficacy, Safety, and Tolerability Study Comparing Dolutegravir Plus Lamivudine With Dolutegravir Plus Tenofovir/Emtricitabine in Treatment naïve HIV Infected Subjects (Gemini 1)

PHASE3CompletedINTERVENTIONAL
Enrollment

719

Participants

Timeline

Start Date

July 21, 2016

Primary Completion Date

March 29, 2018

Study Completion Date

August 15, 2022

Conditions
Infection, Human Immunodeficiency VirusHIV Infections
Interventions
DRUG

Dolutegravir (DTG)

DTG is available as 50 mg white, round, biconvex, film coated tablet debossed on one side with 'SV 572' and on the other side with '50'. The tablets are packaged into high density polyethylene (HDPE) bottles with induction seals and child resistant closures. Each 45 ml bottle contains 30 tablets and a desiccant. DTG 50 mg tablet will be orally administered once daily with or without food upto 148 weeks.

DRUG

Lamivudine (3TC)

Lamivudine is available as swedish orange, 'AA' sized elongated double blind HPMC capsules containing 300 mg lamivudine to visually match overencapsulated TDF/FTC FDC tablet. The capsules are packaged into HDPE bottles with induction seals and child resistant closures. Each 150 mL bottle contains 30 capsules and a desiccant. Overencapsulated 3TC 300 mg tablet will be orally administered once daily with or without food upto 96 weeks. From Week 96 to Week 148, lamivudine will be dispensed as 300 mg white, diamond shaped, scored, film coated tablets debossed with 'GX CJ7' on both sides, packed in over labelled HDPE bottles with child-resistant closures each containing 30 tablets.

DRUG

Tenofovir disoproxil fumarate/Emtricitabine (TDF/FTC FDC)

Tenofovir disoproxil fumarate and Emtricitabine are available as swedish orange, 'AA' sized elongated double blind HPMC capsules containing 300 mg TDF and 200 mg FTC to visually match overencapsulated 3TC tablet. The capsules are packaged into HDPE bottles with induction seals and child resistant closures. Each 150 mL bottle contains 30 capsules and a desiccant. Overencapsulated tenofovir disoproxil fumarate/emtricitabine tablet will be orally administered once daily with or without food upto 96 weeks. From Week 96 to Week 148, tenofovir disoproxil fumarate/emtricitabine will be dispensed as 300/200 mg white, blue, capsule shaped, film coated tablets debossed with 'GILEAD' on one side and '701' on another side, packed in overlabelled HDPE bottles with polypropylene childresistant closures each containing 30 tablets and a desiccant.

Trial Locations (90)

100

GSK Investigational Site, Taipei

824

GSK Investigational Site, Kaohsiung City

1000

GSK Investigational Site, Brussels

1070

GSK Investigational Site, Brussels

1141

GSK Investigational Site, Buenos Aires

1200

GSK Investigational Site, Brussels

1202

GSK Investigational Site, Buenos Aires

2000

GSK Investigational Site, Antwerp

2010

GSK Investigational Site, Darlinghurst

GSK Investigational Site, Sydney

4006

GSK Investigational Site, Fortitude Valley

7925

GSK Investigational Site, Observatory, Cape Town

10439

GSK Investigational Site, Berlin

11217

GSK Investigational Site, Taipei

13003

GSK Investigational Site, Marseille

14004

GSK Investigational Site, Córdoba

15706

GSK Investigational Site, Santiago de Compostela

16132

GSK Investigational Site, Genoa

18102

GSK Investigational Site, Allentown

20037

GSK Investigational Site, Washington D.C.

20080

GSK Investigational Site, Donostia / San Sebastian

20127

GSK Investigational Site, Milan

20146

GSK Investigational Site, Hamburg

21052

GSK Investigational Site, Busto Arsizio (VA)

25123

GSK Investigational Site, Brescia

27100

GSK Investigational Site, Pavia

28007

GSK Investigational Site, Madrid

28031

GSK Investigational Site, Madrid

28034

GSK Investigational Site, Madrid

28911

GSK Investigational Site, Madrid

30033

GSK Investigational Site, Decatur

31059

GSK Investigational Site, Toulouse

32806

GSK Investigational Site, Orlando

33407

GSK Investigational Site, West Palm Beach

34982

GSK Investigational Site, Ft. Pierce

35128

GSK Investigational Site, Padua

36312

GSK Investigational Site, Vigo

40138

GSK Investigational Site, Bologna

41944

GSK Investigational Site, Daegu

42121

GSK Investigational Site, Reggio Emilia

44100

GSK Investigational Site, Ferrara

44160

GSK Investigational Site, Guadalajara

45122

GSK Investigational Site, Essen

45170

GSK Investigational Site, Zapopan

46014

GSK Investigational Site, Valencia

46202

GSK Investigational Site, Indianapolis

48072

GSK Investigational Site, Berkley

49241

GSK Investigational Site, Busan

53127

GSK Investigational Site, Bonn

63108

GSK Investigational Site, St Louis

64111

GSK Investigational Site, Kansas City

75013

GSK Investigational Site, Paris

75475

GSK Investigational Site, Paris

75571

GSK Investigational Site, Paris

77401

GSK Investigational Site, Bellaire

80336

GSK Investigational Site, Munich

85015

GSK Investigational Site, Phoenix

94275

GSK Investigational Site, Le Kremlin-Bicêtre

105275

GSK Investigational Site, Moscow

196645

GSK Investigational Site, Saint Petersburg

302040

GSK Investigational Site, Oryol

400348

GSK Investigational Site, Cluj-Napoca

445846

GSK Investigational Site, Toliyatti

620149

GSK Investigational Site, Yekaterinburg

660049

GSK Investigational Site, Красноярск

800179

GSK Investigational Site, Galati

01199

GSK Investigational Site, Springfield

27599-7064

GSK Investigational Site, Chapel Hill

02906

GSK Investigational Site, Providence

C1181ACH

GSK Investigational Site, Ciudad Autonoma de Buenos Aires

C1405CKC

GSK Investigational Site, Ciudad Autónoma de Buenos Aires

K1H 8L6

GSK Investigational Site, Ottawa

H2L 4E9

GSK Investigational Site, Montreal

H2L 4P9

GSK Investigational Site, Montreal

00149

GSK Investigational Site, Roma

06470

GSK Investigational Site, Distrito Federal

3015 CE

GSK Investigational Site, Rotterdam

3079 DZ

GSK Investigational Site, Rotterdam

3000-075

GSK Investigational Site, Coimbra

1169-050

GSK Investigational Site, Lisbon

4369-004

GSK Investigational Site, Porto

137-701

GSK Investigational Site, Seoul

152-703

GSK Investigational Site, Seoul

03010

GSK Investigational Site, Alicante

08916

GSK Investigational Site, Badalona

03203

GSK Investigational Site, Elche (Alicante)

08304

GSK Investigational Site, Mataró

SE1 9RT

GSK Investigational Site, London

SW10 9NH

GSK Investigational Site, London

M8 5RB

GSK Investigational Site, Manchester

Sponsors
All Listed Sponsors
collaborator

PPD Development, LP

INDUSTRY

collaborator

GlaxoSmithKline

INDUSTRY

lead

ViiV Healthcare

INDUSTRY