Thorough ECG (Electrocardiogram) and Drug Interaction Study With Anetumab Ravtansine and Itraconazole

PHASE1CompletedINTERVENTIONAL
Enrollment

63

Participants

Timeline

Start Date

September 7, 2016

Primary Completion Date

June 27, 2018

Study Completion Date

August 5, 2019

Conditions
Medical Oncology
Interventions
DRUG

Anetumab ravtansine (BAY94-9343)

Anetumab ravtansine given IV On Day 1 of each 21-day treatment cycle Part 1: Cycle 1 Day 1: 6.5 mg/kg of body weight (BW) Cycle 2 Day 1: 0.6 mg/kg BW Part 2: Cycle 1 Day 1: 6.5 mg/kg BW Cycle 2 Day 1: 6.5 mg/kg BW (planned dose) Continuous treatment: Cycles ≥3 Day 1: 6.5 mg/kg BW once every 3 weeks (Q3W)

DRUG

Itraconazole

Itraconazole 100 mg oral capsules given by mouth Cycle 1 (Day 18): 200 mg twice daily (BID) (Days 19 - 21): 200 mg once daily (QD) Cycle 2 (Days 1-8): 200 mg QD 12 days in total (Part 1 or Part 2)

Trial Locations (18)

1200

CU Saint-Luc/UZ St-Luc, Bruxelles - Brussel

2148

Blacktown Cancer & Haematology Centre, Blacktown

3122

Epworth HealthCare, Richmond

9000

UZ Gent, Ghent

13005

Hôpital de la Timone - Marseille, Marseille

21079

Centre Georges Francois Leclerc Dijon, Dijon

28040

Fundacion Jimenez Diaz (Clinica de la Concepcion), Madrid

29010

Hospital Virgen de la Victoria, Málaga

48202

Henry Ford Health System, Detroit

63110

Washington University School of Medicine, St Louis

75230

Mary Crowley Medical Research Center, Dallas

90404

UCLA-Santa Monica Medical Center, Santa Monica

94010

Hôpital Henri Mondor, Créteil

44106-2602

University Hospitals Cleveland Medical Center, Cleveland

1066 CX

Nederlands Kanker Instituut, Amsterdam

1081 HV

VUmc, Amsterdam

6525 GA

Universitair Medisch Centrum St. Radboud, Nijmegen

08035

Ciutat Sanitària i Universitaria de la Vall d'Hebron, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY