Bilateral Pallidal Stimulation in Patients With Advanced Parkinson's Disease-LATESTIM

"Patients in the GPi group will be implanted with DBS-electrodes within 6 weeks after randomisation. The stimulation parameters and the medical treatment are adjusted for optimal control of motor and non-motor signs and symptoms according to published guidelines using a specified algorithm. The stimulation parameters are recorded at the beginning and at the end of each post-surgical assessment.~Best medical treatment is applied in combination with GPi-DBS."

Patients will receive optimized medical treatment according to published evidence based guidelines.